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Clostridia - Molecular Biology in the Post-genomic Era (Hardcover)
Loot Price: R5,863
Discovery Miles 58 630
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Clostridia - Molecular Biology in the Post-genomic Era (Hardcover)
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The genus Clostridium represents a heterogeneous group of anaerobic
spore-forming bacteria, comprising prominent toxin-producing
species, such as C. difficile, C. botulinum, C. tetani, and C.
perfringens, in addition to well-known non-pathogens like
solventogenic C. acetobutylicum. In the last decade, several
clostridial genomes have been deciphered and post-genomic studies
are currently underway. The advent of newly developed, genetic
manipulation tools have permitted functional-based and systems
biology analyses of several clostridial strains. Research in this
area is at a very exciting stage. In this book, internationally
recognized Clostridium experts critically review the most important
aspects of clostridial research, providing the first coherent
picture of the organism's molecular and cellular biology in this
post-genomic era. The first major focus of the book is the genetics
and molecular biology of the major clostridial toxins including:
botulinum and tetanus neurotoxins, C. difficile large exotoxins, C.
perfringens enterotoxin, pore-forming and binary bacterial toxins.
Other topics include molecular epidemiology of C. botulinum and C.
difficile, metabolic networks in C. acetobutylicum, development of
genetic knock-out systems for clostridia, surface structures, anti
tumor potential of clostridia, and antibiotic resistance
determinants in C. difficile.
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