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Pathophysiology and Pharmacology of Erythropoietin (Paperback, Softcover reprint of the original 1st ed. 1992)
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Pathophysiology and Pharmacology of Erythropoietin (Paperback, Softcover reprint of the original 1st ed. 1992)
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I am honored to be invited to prepare a foreword for the
proceedings of the Second International Lubeck Conference on
Erythropoietin (Epo). I congratulate Wolfgang Jelkmann, Horst Pagel
and Christoph Weiss for their organization of an excellent program
for this conference which updated all of us on the advances made in
erythropoietin research during the past few years since the first
conference in June of 1988. I am sure that Professor Paul Carnot,
had he been present at this conference, would be very pleased and
proud of the advances made in the field of erythropoietin since his
and Madame DeFlandre's seminal finding in 1906 (1) that rabbits
produced a humoral substance following bleeding which controls red
blood cell production. The reports by Hjort in 1936 (2) and by
Erslev in 1953 (3) that large volumes of plasma or serum from
rabbits following a bleeding stimulus, when injected into normal
donor rabbits, produced a reticulocytosis, were very significant in
confirming the existence of a humoral factor which controls
erythropoiesis. Reissmann's parabiotic rat experiments in 1950 (4)
reawakened interest in erythropoietin when he proved that hypoxia
stimulated the production of a factor which regulates red cell
produc tion. The studies of several investigators such as Jacobson
et al. (5), Fisher and Birdwell (6), Kuratowska et al. (7) and
Nathan et al."
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