0
Your cart

Your cart is empty

Books > Science & Mathematics > Biology, life sciences > Biochemistry > Toxicology (non-medical)

Buy Now

Neurotoxicity Risk Assessment for Human Health - Principles and Approaches (Paperback, Revised edition) Loot Price: R1,191
Discovery Miles 11 910

Neurotoxicity Risk Assessment for Human Health - Principles and Approaches (Paperback, Revised edition)

Ilo, Unep, Who?, Ipcs

Series: Environmental Health Criteria, No. 223

 (sign in to rate)
Loot Price R1,191 Discovery Miles 11 910 | Repayment Terms: R112 pm x 12*

Bookmark and Share

Expected to ship within 10 - 15 working days

This publication summarizes the scientific knowledge base on which principles and methods involved in neurotoxicity risk assessment are based. It is aimed at providing a framework for public health officials, research and regulatory scientists and risk managers on the use and interpretation of neurotoxicity data from human and animal studies and it discusses emerging methodological approaches to studying neurotoxicity. The introductory chapter examines definitions and critical concepts in neurotoxicity and looks at the criteria for quality of data used in risk assessment. This is followed by a detailed discussion of the structure and function of the nervous system, of the special susceptibilities of the human fetus, children and the elderly and of the types of effects on the nervous system. Recent progress in developing validated methods for detecting neurotoxicity in humans is investigated, as is our understanding of the factors that affect the validity and reliability of human neurotoxicological studies. Sources of human data include accidental and occupational exposures, case-studies, clinical evaluations, epidemiological studies, and field and laboratory studies. Standardized neuropsychological tests, validated computer-assisted test batteries, neurophysiological and biochemical tests, and refined imaging techniques have been improved and become well established. The most extensive section reviews data derived from experimental animal models. Batteries of functional tests have been developed, validated and used extensively in neurotoxicological studies. Many different types of behavioural tests have been used to assess chemical-induced changes in sensory, motor and cognitive function, whereas neurophysiological measures have been standardized to assess chemical-induced sensory and motor function. The final chapter examines the steps involved in neurotoxicity risk assessment: hazard identification, dose-response assessment, exposure assessment and risk characterization. The application of risk assessment principles for neurotoxicants is similar to that of other non-cancer end-points, except that issues of reversibility, compensation and recovery of function in the nervous system require special consideration. This document provides guidance on neurotoxicity risk assessment at a broad international level.

General

Imprint: World Health Organization
Country of origin: Switzerland
Series: Environmental Health Criteria, No. 223
Release date: 2001
First published: June 2001
Authors: Ilo • Unep • Who? • Ipcs
Dimensions: 229 x 152 x 13mm (L x W x T)
Format: Paperback - Trade
Pages: 223
Edition: Revised edition
ISBN-13: 978-92-4-157223-1
Categories: Books > Medicine > Clinical & internal medicine > Neurology & clinical neurophysiology
Books > Science & Mathematics > Biology, life sciences > Biochemistry > Toxicology (non-medical)
Books > Medicine > General issues > Public health & preventive medicine > Personal & public health > Environmental factors
Promotions
LSN: 92-4-157223-X
Barcode: 9789241572231

Is the information for this product incomplete, wrong or inappropriate? Let us know about it.

Does this product have an incorrect or missing image? Send us a new image.

Is this product missing categories? Add more categories.

Review This Product

No reviews yet - be the first to create one!

You might also like..

The Poisoners - On South Africa's Toxic…
Imraan Coovadia Paperback R320 R295 Discovery Miles 2 950
Handbook of Arsenic Toxicology
Swaran Jeet Singh Flora Hardcover R4,620 Discovery Miles 46 200
Advances in Marine Biology, Volume 79
Charles Sheppard Hardcover R4,593 Discovery Miles 45 930
Chiral Pesticides - Stereoselectivity…
A. Wayne Garrison, Jay Gan, … Hardcover R2,899 Discovery Miles 28 990
Advances in Human Vector Control
J. Marshall Clark, Jeffrey Bloomquist, … Hardcover R2,781 Discovery Miles 27 810
Neurotoxicity of Drugs of Abuse, Volume…
Lucio G. Costa, Michael Aschner, … Hardcover R5,906 R4,940 Discovery Miles 49 400
Occupational Neurotoxicology, Volume 7
Michael Aschner, Lucio G. Costa, … Hardcover R5,922 R4,957 Discovery Miles 49 570
Marine Neurotoxins, Volume 6
Antonello Novelli, Maria Teresa Fernandez Sanchez, … Hardcover R6,617 R5,536 Discovery Miles 55 360
Pharmaceuticals in Marine and Coastal…
Juan Carlos Duran-Alvarez, Blanca Jimenez-Cisneros Paperback R4,213 Discovery Miles 42 130
Neurotoxicity of Metals: Old Issues and…
Michael Aschner, Lucio G. Costa Hardcover R5,929 R4,964 Discovery Miles 49 640
Drink? - The New Science of Alcohol and…
David Nutt Paperback R469 R438 Discovery Miles 4 380
Animal Feed Additives
Pankaj Singh Hardcover R4,966 Discovery Miles 49 660

See more

Partners