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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Cytoskeleton, Volume 12 (Hardcover)
Loot Price: R3,406
Discovery Miles 34 060
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Cytoskeleton, Volume 12 (Hardcover)
Series: Advances in Molecular & Cell Biology
Expected to ship within 12 - 19 working days
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It is now clear from a wide range of research that cytoplasm is not
merely a buffered solution of proteins and enzymes but contains a
series of complex filamentous structures. The cytoskeleton is the
collective term given to these filaments. There is a considerable
amount of data available on the protein composition of the major
filament systems (microfilaments, microtubules, and intermediate
filaments) but we are still comparatively ignorant about the role
of the cytoskeleton in cell physiology. However such major
cytoplasmic components (actin and tubulin, the monomeric
constituents of microfilaments and microtubules, are major cell
proteins) must have important roles to play in cell function, and
investigations into the functional role of the cytoskeleton
currently represent a major area of cell biological research.
In recent years rapid advances in molecular biology have begun to
influence research on the cytoskeleton. This trend is sure to
continue and the techniques of molecular biology and genetics are
set to make major contributions to our understanding of the
cytoskeleton, as illustrated in this volume by several reviews; the
use of transfection techniques by Ben-Ze'ev, the power of
Drosophila genetics is described by Fyrberg and the major advances
made in the inesin field using molecular approaches as described by
Cyr et al. The chapters by Fyrberg and Cyr et al. also illustrate
two other areas where major advances in our understanding of the
cytoskeleton is occuring; the great array of different motor
proteins involved in intracellular movements and the study of the
cytoskeleton in developmental biology.
Overall, Volume 12 in this series illuminates our increasing
knowledge of the important roles of the cytoskeleton in cell
function, particularly how it is central to metabolic organization,
intracellular transport, interactions with matrix, and nerve
function. Our knowledge of the cytoskeleton is now reaching a stage
where it is clear that abnormalities in the organization of the
cytoskeleton can lead to important clinical manifestations of
disease; an example of how such research is now impinging on
medical science is presented in the final chapter by Lane on
keratin diseases.
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