Nitric Oxide, Cytochromes P450, and Sexual Steroid Hormones (Paperback, Softcover reprint of the original 1st ed. 1997)

The discovery of mammalian nitric oxide (NO-) synthesis from I-ar- ginine has led to profound increases in our understanding of basic physiological and pathophysiological processes. This understanding has been achieved by major advances in several areas. Three major ni- tric oxide synthase (NOS) isoforms have been identified at the protein and gene level and their specific tissue localization has been linked to processes subject to regulation by NO-. The molecular basis for the di- verse effects of NO- on cell function has been shown to derive from its chemical reactivity with oxygen-containing species and both heme and non-heme iron-dependent enzymes. The potential regulation of heme- dependent enzymes such as cytochromes P450, guanylate cyclase, cy- clooxygenase, and mitochondrial cytochrome oxidase continues to emerge as a key area in NO- research. In addition, it has become clear that the expression of NOS isoforms and NO- release from cells is subject to regulation by sexual steroids and that, in tum, NO- has the potential to regulate steroid biosynthesis via inhibition of cytochromes P450 involved in steroidogenesis. These recent observations on interactions between the NO-/NOS and cytochrome P450/sexual steroid pathways have important implica- tions for understanding fundamental mechanisms involved in endocri- nological processes. They are also likely to lead to novel insights and novel therapeutic approaches for the management of pathophysiologi- cal conditions associated with alterations in sexual steroid hormones.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Ernst Schering Foundation Symposium Proceedings, 21
Release date:	December 2012
First published:	1997
Editors:	Jack R. Jr. Lancaster • J.F. Parkinson
Dimensions:	210 x 148 x 17mm (L x W x T)
Format:	Paperback
Pages:	310
Edition:	Softcover reprint of the original 1st ed. 1997
ISBN-13:	978-3-662-03505-4
Categories:	Books > Medicine > Nursing & ancillary services > Pharmacy / dispensing Books > Medicine > Clinical & internal medicine > Endocrinology > General Books > Medicine > Other branches of medicine > Pharmacology > General Books > Science & Mathematics > Biology, life sciences > Biochemistry > General Promotions
LSN:	3-662-03505-7
Barcode:	9783662035054

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