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Books > Science & Mathematics > Biology, life sciences > Biochemistry
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Frontiers in Bioactive Lipids (Paperback, Softcover reprint of the original 1st ed. 1996)
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Discovery Miles 37 040
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Frontiers in Bioactive Lipids (Paperback, Softcover reprint of the original 1st ed. 1996)
Series: Gwumc Department of Biochemistry and Molecular Biology Annual Spring Symposia
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Recent advances in our understanding of the fundamental role of
bioactive lipids in normal and abnormal physiology was the theme of
the XVlth International Spring Sympo- 6-9, 1996 at the George
Washington University School sium on Health Sciences held on May of
Medicine in Washington, D.C. Over 250 participants shared their
latest findings on fundamental mechanisms in lipid metabolism,
transport, and signal transduction. Most of the papers presented at
the plenary sessions have been collected in this volume, which is
divided into seven parts. The focus of Part I is on the new roles
that fatty acids and esters play in cellular function. These
activities include regulation of gene expression, control of
eicosanoid-me- diated responses, and intracellular calcium
sequestration. Most biological effects of fatty acids, esters, and
phospholipids are transmitted via the interaction of these lipid
molecules with specific lipid binding proteins. The chapters in
Part II detail the involvement of these in the transport of fatty
acids, fatty acyl CoA esters, and phospholipids, and in the
proteins modulation of the fatty acid-induced activation of the
peroxisome proliferator-activated receptors. The study of
arachidonic acid metabolism continues to be the subject of intense
interest and research. A number of studies in Part III deal with
the substantial differences between the constitutive prostaglandin
H synthase isozyme (PGHS-l or COX-I) and the inducible form PGHS-2
(COX-2) regarding compartmentation, control, and expression.
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