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Natural Antimicrobial Agents (Hardcover, 1st ed. 2018)
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Natural Antimicrobial Agents (Hardcover, 1st ed. 2018)
Series: Sustainable Development and Biodiversity, 19
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Documenting the latest research in the field of different
pathogenic organisms, this book presents the current scenario about
promising antimicrobials in the following areas: Part I. Plants as
source of antibacterials, Part II. Naturally occurring antifungal
natural products, Part III. Antiparasitic natural products, Part
IV. Antiviral natural products. Renowned scientists from the globe
have been selected as authors to contribute chapters. Use of plants
for various ailments is as old as human civilization and continuous
efforts are being made to improve medicinal plants or to product
their bioactive secondary metabolites in high amounts through
various technologies. About 200,000 natural products of plant
origin are known and many more are being identified from higher
plants and micro-organisms. Some plants based drugs are used since
centuries and there is no alternative medicine for many such drugs
as cardiac glycosides. Drug discovery from medicinal plants or
marine micro-organisms continues to provide an important source of
new drug leads. Research on new antibacterials represents a real
and timely challenge of this century, particularly for the
treatment of infections caused by clinical isolates that show
multidrug resistance. The main microorganisms involved in the
resistance process have been identified and given the acronym
ESKAPE for Enterococcus faecium, Staphylococcus aureus, Klebsiella
pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa and
Enterobacteriaceae. Multidrug resistant Mycobacterium tuberculosis
including highly drug-resistant strains (XDR-TB) has also emerged
as one of the most important clinical challenges of this century.
Plants of diverse taxa and marine micro-organisms are rich source
of these antimicrobials. An attempt has been made to compile the
recent information about natural sources of antibacterials and
their sustainable utilization. Increased panic of these pathogens
warrants a growing demand for research to undertake the threat of
multidrug resistance. The search for new antifungal, antiparasitic
and antiviral natural products is far from devoid of interest.
According to the WHO report in 2013, malaria still represents some
207 million cases worldwide and more than 3 billion of people are
still exposed to this risk. Similarly, about 350 million people are
considered at risk of contracting leishmaniasis. The fight against
some viruses also requires that the research on natural products
continue. For example, even if an antiretroviral with direct action
was recently approved in Europe in 2013, its high cost does not
allow to offer it to an exposed population in countries where the
cost of drugs remains a problem for a large part of the population.
These books are useful to researchers and students in microbiology,
biotechnology, pharmacology, chemistry and biology as well as
medical professionals.
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