The Textbook of Ion Channels is a set of three volumes that
provides a wide-ranging reference source on ion channels for
students, instructors, and researchers. Ion channels are membrane
proteins that control the electrical properties of neurons and
cardiac cells, mediate the detection and response to sensory
stimuli like light, sound, odor, and taste, and regulate the
response to physical stimuli like temperature and pressure. In
non-excitable tissues, ion channels are instrumental for the
regulation of basic salt balance that is critical for homeostasis.
Ion channels are located at the surface membrane of cells, giving
them the unique ability to communicate with the environment, as
well as the membrane of intracellular organelles, allowing them to
regulate internal homeostasis. Ion channels are fundamentally
important for human health and diseases, and are important targets
for pharmaceuticals in mental illness, heart disease, anesthesia,
pain and other clinical applications. The modern methods used in
their study are powerful and diverse, ranging from single
ion-channel measurement techniques to models of ion channel
diseases in animals, and human clinical trials for ion channel
drugs. Volume III includes coverage of key ion channel regulators
and their mechanisms, the role of ion channels working in concert
in selected physiological systems, and examples of ion channel
mutations and dysfunction in a selection of diseases. Chapters on
ion channel regulation include splice variants, calcium-calmodulin
regulation, regulation by G-proteins, and lipids. A selection of
ion channels in physiological systems includes ion channels of the
heart, ion channels in immune cells and their role in pancreatic
beta cells and regulation of insulin secretion, and the role of
channels in sperm and eggs. While disease mechanisms are integrated
into the chapters of Volume II, Volume III offers special
consideration of ion channels in epilepsy, cystic fibrosis, and
pain syndromes. All three volumes give the reader an introduction
to fundamental concepts needed to understand the mechanism of ion
channels, a guide to the technical aspects of ion channel research,
offer a modern guide to the properties of major ion channel
families, and include coverage of key examples of regulatory,
physiological, and disease roles for ion channels.
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