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Genetics of Bacterial Polysaccharides (Hardcover)
Loot Price: R7,278
Discovery Miles 72 780
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Genetics of Bacterial Polysaccharides (Hardcover)
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Bacterial surface or secreted polysaccharides are molecules that
can function as barriers to protect bacterial cells against
environmental stresses, as well as act as adhesins or recognition
molecules. In some cases, these molecules are immunodominant
antigens eliciting a vigorous immune response, while in other cases
the expression of polysaccharides camouflages the bacteria from the
immune system. Until recently, most studies on the enzymatic steps
and regulation of these molecules were performed on the enteric
gram negative bacteria Escherichia coli and Salmonella typhimurium.
With the advent of modern bacterial genetics, techniques such as
construction and characterization of polysaccharide mutants,
cloning of genes and complementation of these mutations, and
expression of polysaccharides in heterologous bacterial hosts has
prompted investigations into the roles and functions of these
molecules for many different bacteria. Here, we present the genetic
analysis of polysaccharides from a number of bacteria pathogenic to
humans and one symbiotic with plants in hopes that similarities in
the experimental approaches as well as finding s from such
investigations may lead to a general understanding of
polysaccharide synthesis and regulation in various bacteria.
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