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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Cancer Cell Lines Part 2 (Paperback, Softcover reprint of the original 1st ed. 1999)
Loot Price: R5,789
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Cancer Cell Lines Part 2 (Paperback, Softcover reprint of the original 1st ed. 1999)
Series: Human Cell Culture, 2
Expected to ship within 10 - 15 working days
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Continuous cell lines derived from human cancers are the mostwidely
used resource in laboratory-based cancer research. The first 3
volumes of this series on Human Cell Culture are devoted to these
cancer cell lines. The chapters in these first 3 volumes have a
common aim. Their purpose is to address 3 questions offundamental
importance to the relevanceof human cancer cell lines as model
systems of each type of cancer: 1. Do the cell lines available
accurately represent the clinical presentation? 2. Do the cell
lines accurately represent the histopathology of the original
tumors? 3. Do the cell lines accurately represent the molecular
genetics of this type of cancer? The cancer cell lines available
are derived, in most cases, from the more aggressive and advanced
cancers. There are few cell lines derived from low grade
organ-confined cancers. This gap can be filled with conditionally
immortalized human cancer cell lines. We do not know why the
success rate for establishing cell lines is so low for some types
of cancer and so high for others. The histopathology of the tumor
of origin and the extent to which the derived cell line retains the
differentiated features of that tumor are critical. The concept
that a single cell line derived from a tumor at a particular site
is representative oftumors at that site is naive and misleading."
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