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Hormonal Carcinogenesis II - Proceedings of the Second International Symposium (Paperback, Softcover reprint of the original 1st ed. 1996)
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Hormonal Carcinogenesis II - Proceedings of the Second International Symposium (Paperback, Softcover reprint of the original 1st ed. 1996)
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For those of us who have labored in the field of hormonal
carcinogenesis, it has been most gratifying to see its rapid growth
and increasing relevance in recent years. Although many factors and
forces have contributed to this phenomenon, a few appear
particularly significant. Perhaps foremost is the realization that
two of the most prevalent cancers which afflict women and men; that
is, breast and prostate, have essential hormonal component(s) to
their etiologies. This should not surprise us since the high
frequency of these cancers in human populations has to date not
been attributed to any exogenous physical, environmental, or
dietary factor(s). A similar argument may be applied to other less
prevalent but equally important cancers including ovarian,
endometrial, testicular, cervico- vaginal, pituitary, thyroid, and
sex hormone-associated hepatic neoplasms. The Office of Research on
Women's Health and many women's interest groups have been
instrumental in fostering research and public awareness on women's
cancers. Similar concern is beginning to emerge for solely male
cancers by other groups. To illustrate an example of the potential
pervasive role of hormones in the human, particularly sex hormones,
Figure I depicts the endogenous and known exogenous exposures to
estrogens and progestins during a woman's lifetime, which may
contribute to increased risk for hormonally-associated cancers . .
= iii M. A. P. _ GI en 2 PoOlmenopauoal ~ EstrogDn ~ Proge. tln GI
en J\ Ovulatory _ 2 Cyel. iii W DES EIP Menotr". 1 Ol,order.
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