Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
|
Buy Now
Immunogenetics of Autoimmune Disease (Hardcover, 2006 ed.)
Loot Price: R4,339
Discovery Miles 43 390
|
|
Immunogenetics of Autoimmune Disease (Hardcover, 2006 ed.)
Series: Medical Intelligence Unit
Expected to ship within 10 - 15 working days
|
utoimmunity is the downstream outcome of a rather extensive and
coordinated series of events that include loss of self-tolerance,
peripheral lymphocyte Aactivation, disruption of the blood-systems
barriers, cellular infiltration into the target organs and local
inflammation. Cytokines, adhesion molecules, growth factors,
antibodies, and other molecules induce and regulate critical cell
functions that perpetuate inflammation, leading to tissue injury
and clinical phenotype. The nature and intensity of this response
as well as the physiological ability to restore homeostasis are to
a large extent conditioned by the unique amino acid sequences that
define allelic variants on each of the numerous participating mol
ecules. Therefore, the coding genes in their germline configuration
play a primary role in determining who is at risk for developing
such disorders, how the disease progresses, and how someone
responds to therapy. Although genetic components in these diseases
are clearly present, the lack of obvious and homogeneous modes of
transmission has slowed progress by prevent ing the full
exploitation of classical genetic epidemiologic techniques.
Furthermore, autoimmune diseases are characterized by modest
disease risk heritability and m- tifaceted interactions with
environmental influences. Yet, several recent discoveries have
dramatically changed our ability to examine genetic variation as it
relates to human disease. In addition to the development of
large-scale laboratory methods and tools to efficiently recognize
and catalog DNA diversity, over the past few years there has been
real progress in the application of new analytical and data-manage
ment approaches.
General
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!
|
|
Email address subscribed successfully.
A activation email has been sent to you.
Please click the link in that email to activate your subscription.