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Biological Role of Inorganic Pyrophosphate (Paperback, Softcover reprint of the original 1st ed. 2001)
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Biological Role of Inorganic Pyrophosphate (Paperback, Softcover reprint of the original 1st ed. 2001)
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Dr. Heinonen reviews and critically evaluates the scientific
literature on the biological role of inorganic pyrophosphate (PPi )
published from 1940 to the end of 1999. He describes and classifies
all known biochemical reactions that produce Ppi; describes and
evaluates all published methods used in biological Ppi; and
compiles and critically evaluates information on the concentration
of PPi (with the conclusion that, contrary to common belief, PPi
exists throughout the living world in rather high concentrations).
Many reactions in which PPi is used as a biochemical energy source
instead of ATP have been described in recent decades, especially in
bacteria, protists, and plants. These reactions are evaluated from
the bioenergetic and regulatory points of view. Also considered is
the possible role of PPi as a source of biochemical energy in the
primitive phases of life, before ATP. Data is presented on the
regulatory role of PPi in living systems, such as activities of
enzymes, fidelity of syntheses of macromolecules, and proliferation
of cells. PPi may also regulate the formation and dissolution of
bone as well as pathologic calcification of soft tissues and the
formation of urinary stones. The formation of calcium pyrophosphate
dihydrate crystals in the extracellular fluids of joints cause the
disease called pseudogout. Biological Role of Inorganic
Pyrophosphate book is a unique and invaluable source of references
(about 1120) and summarized data for professionals who study or
plan to study the role of PPi in living systems. Many different
branches of science (biochemistry, microbiology, bioenergetics,
plant physiology, parasitology, evolution, orthopedics,
rheumatology) have involvement with PPi. This book sums up
available knowledge in one place and will help scientists cross
disciplinary boundaries.
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