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Books > Medicine > Other branches of medicine > Pharmacology > Medical toxicology
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Slow Synaptic Responses and Modulation (Paperback, 2000 ed.)
Loot Price: R1,515
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Slow Synaptic Responses and Modulation (Paperback, 2000 ed.)
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Information flow as nerve impulses in neuronal circuits is
regulated at synapses. The synapse is therefore a key element for
information processing in the brain. Much attention has been given
to fast synaptic transmission, which predominantly regulates
impulse-to-impulse transmission. Slow synaptic transmission and
modu lation, however, sometimes have been neglected in considering
and attempting to understand brain function. Slow synaptic
potentials and modulation occur with a considerable delay in
response to the accumulation of synaptic and modulatory inputs. In
these contexts, they are plastic in nature and play important roles
in information processing in the brain. A symposium titled "Slow
Synaptic Responses and Modulation" was held as the satellite
symposium to the 75th Annual Meeting of the Physiological Society
of Japan on March 30-31, 1998, in Kanazawa. The theme was selected
not only for the reason mentioned above, but also because of the
considerable involvement of many Japanese scholars in establishing
the basic issues. Following the dawn of synaptic physiological
research, as Sir John Eccles, Sir Bernard Katz, and Professor
Stephen Kuffler carried out pioneer work, Professor Kyozou Koketsu
and Professor Benjamin Libet, the students of Sir John Eccles, and
their colleagues established the concept of slow synaptic responses
and modulation by studying vertebrate sympathetic ganglia. Since
then, the concept has been ex panded with detailed investigations
of both peripheral and central synapses at the levels of single ion
channels, intracellular Ca"+ dynamics, intracellular transduc tion
mechanisms, and genes.
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