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Books > Medicine > Other branches of medicine > Pathology > Medical microbiology & virology
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Hepatitis C Virus Treatment - Highly Effective Therapy with Direct Acting Antivirals and Associated Viral Resistance (Hardcover, 1st ed. 2017)
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Hepatitis C Virus Treatment - Highly Effective Therapy with Direct Acting Antivirals and Associated Viral Resistance (Hardcover, 1st ed. 2017)
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This book introduces readers to Direct Acting Antiviral (DAAs)
agents, newly developed drugs to treat chronic hepatitis C virus
infection, which have an excellent anti-viral effect on virus
replication. These drugs have been developed to enhance the effect
of interferon and ribavirin, as the resistant strains against each
drug have been described both in vitro and in vivo and the
existences of naturally occurring variants have been reported.
However, since the combination of different classes of DAAs is
sufficient to completely eradicate the virus without the need for
interferon or ribavirin, the current treatment regimen does not
include interferon. Ribavirin is used in combination with
sofosbuvir, a potent polymerase inhibitor, to enhance its antiviral
effects. Hepatitis C Virus Treatment offers readers a comprehensive
guide to hepatitis C; describing the resistance profiles against
these drugs and shedding light on the difficulties involved in DAA
therapy and the direction of future treatments, it will equip
doctors to understand the essentials of treating the disease. It
also describes in detail new and innovative DAA treatments, the
effects of the agents, and the characteristics of resistance,
providing cutting-edge information not only for hepatologists, but
also for researchers, clinical residents, and medical students.
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