While the genomic revolution has quickly led to the deposit of more
than 30,000 structures in the protein data bank (PDB), less than
one percent of those contributions represent membrane proteins
despite the fact that membrane proteins constitute some 20 percent
of all proteins. This discrepancy becomes significantly troublesome
when it is coupled with the fact that 60 percent of current drugs
are based on targeting this group of proteins, a trend that does
not seem likely to reverse.
Structural Genomics on Membrane Proteins provides an excellent
overview on novel research in bioinformatics and modeling on
membranes, as well as the latest technological developments being
employed in expression, purification, and crystallography to obtain
high-resolution structures on membrane proteins. This cutting-edge
work also explains the difficulties facing researchers-both
technical and ethical-that have slowed the process.
Structural Genomics on Membrane Proteins provides researchers
with an unprecedented look at the novel technologies that will
ultimately allow them to conquer the last frontier in structural
biology, leading to accelerated breakthroughs in drug
discovery.
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