Despite progress in genetic research, knowledge about the exact
structure of the chromosome continues to provide a challenge. Much
of that challenge lies with the need for improved tools and methods
that researchers require to perform novel analyses beyond the DNA
level. Fortunately, rapid advances in nanotechnology, are now being
employed to examine, analyze, and manipulate biological material at
the chromosome level. Chromosome Nanoscience and Technology reviews
these advances and their contribution to trends and applications in
chromosome research. In addition to offering a guide to current
progress, this book serves as the culminating report on a Japanese
nanobiology project in the field of chromosome science begun in
2000. The project brought together researchers from disparate
backgrounds that included molecular biology, biochemistry, protein
science, immunology, genetics, anatomy, semiconductor production,
polymer chemistry, material science, microscopy, and informatics,
among others. Looking at chromosomes as nanomaterials, their
contributions cover: Devices for chromosome handling, which
includes the construction and application of nano and micro devices
used for dissecting, analyzing, and manipulating chromosomes
Visualization of chromosomes at nano and micro levels, which
discusses methods for revealing nano-level folding of chromatin
fibers Chromosomes as nanomaterials, which presents a new
chromosome protein framework based on the cataloging of over 200
chromosomal proteins Informatics of chromosome images, which
examines a new chromosome image database system for animals and
plants This project, initiated a few years ago, now lays the
groundwork for those scientists looking to perform further research
in chromosome science. It provides them with starting points, as
well as useful applications and methodology to assist in the long
quest to gain a deepened understanding of life itself.
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