Proteases as Targets for Therapy (Paperback, Softcover reprint of the original 1st ed. 2000)

Proteolytic enzymes and their natural antagonists, the protease inhibitor pro- teins, play a crucial role in the physiology and pathology of living organisms including humans. Remark able advantages revealed their wide functional context. Proteases digest food proteinase in the digestive tract and liberate poly- peptide hormones, stimulating gastric and pancreatic secretion. Proteases are involved during fertilization in sperm - egg interaction, ovulation, ovum implantation and parturition. Proteases of the renin-angiotensin and kallikrein-kinin systems act synergistically to generate blood pressure regu- lating polypeptides. In wound healing a battery of proteases is involved in the proteolytic cascades of clotting, fibrinolysis and tissue repair.Another battery of very different proteases directs the immune defense via several routes, i.e. complement activation, antigen presentation, the generation of chemokines and chemotaxins directing phagocytes to the site of injury or infection and the generation of cell-stimulating factors such as cytokines regulating the inflam- matory response of the organism.Granzymes contribute to the toxicity of lym- phocytes or killer cells,caspases regulate physiological cell death and calpains intracellular signaling cascades. The energy-dependent proteasome-ubiquitin system controls highly efficientl y the activity or level of intracellular proteins, including cell-cycle regulators, transcription and signal transduction factors, oncoproteins and short-lived metabolic enzymes.And this listing is far from complete.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Handbook of Experimental Pharmacology, 140
Release date:	October 2012
First published:	2000
Editors:	Klaus von der Helm • Bruce D. Korant • John C. Cheronis
Dimensions:	235 x 155 x 23mm (L x W x T)
Format:	Paperback
Pages:	410
Edition:	Softcover reprint of the original 1st ed. 2000
ISBN-13:	978-3-642-63023-1
Categories:	Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Medicine > Other branches of medicine > Pharmacology > General Books > Science & Mathematics > Biology, life sciences > Biochemistry > General
LSN:	3-642-63023-5
Barcode:	9783642630231

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