Understanding mechanisms of gene regulation that are independent of
the DNA sequence itself - epigenetics - has the potential to
overthrow long-held views on central topics in biology, such as the
biology of disease or the evolution of species. High throughput
technologies reveal epigenetic mechanisms at a genome-wide level,
giving rise to epigenomics as a new discipline with a distinct set
of research questions and methods. Leading experts from academia,
the biotechnology and pharmaceutical industries explain the role of
epigenomics in a wide range of contexts, covering basic chromatin
biology, imprinting at a genome-wide level, and epigenomics in
disease biology and epidemiology. Details on assays and sequencing
technology serve as an up-to-date overview of the available
technological tool kit. A reliable guide for newcomers to the field
as well as experienced scientists, this is a unique resource for
anyone interested in applying the power of twenty-first-century
genomics to epigenetic studies.
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