Sphingolipids and Metabolic Disease (Hardcover, 2011 ed.)

Current thinking holds that obesity derives primarily from overnutrition (though compelling arguments for other mechanisms, like endocrine disruption by environmental pollutants, also gain support from the literature). In animals, overnutrition is initially handled by adipose tissue expansion; however, exhaustion of this route of lipid sequestering results in oversupply of lipid to other tissues including skeletal muscle, heart, liver, and others. Failure of these tissues to clear excess lipids through either metabolism or sequestration into putatively inert triacylglycerols results in perturbation of bioactive lipid metabolism in cells. In particular, aberrant generation of bioactive sphingolipids is implicated in a multitude of pathological outcomes of metabolic disease including insulin resistance, inflammation, cardiomyopathy, and others. This volume addresses not only the fundamentals of sphingolipid metabolism and analysis, but also the roles of sphingolipids in these disease processes.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	Advances in Experimental Medicine and Biology, 721
Release date:	August 2011
First published:	2011
Editors:	L. Ashley Cowart
Dimensions:	254 x 178 x 15mm (L x W x T)
Format:	Hardcover
Pages:	148
Edition:	2011 ed.
ISBN-13:	978-1-4614-0649-5
Categories:	Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > Metabolism Books > Medicine > Clinical & internal medicine > Diseases & disorders > General
LSN:	1-4614-0649-8
Barcode:	9781461406495

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