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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Immunoreceptor Signaling - A Subject Collection from Cold Spring Harbor Perspectives in Biology (Hardcover)
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Immunoreceptor Signaling - A Subject Collection from Cold Spring Harbor Perspectives in Biology (Hardcover)
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The behavior of lymphocytes in the immune system depends on
encounters with antigens. These bind to immunoreceptors on the
surface of T-cells and B-cells, activating a variety of signal
transduction pathways that control cell survival, proliferation,
differentiation, and effector functions.
Written and edited by experts in the field, this collection from
Cold Spring Harbor Perspectives in Biology includes contributions
covering the structures of the T-cell and B-cell immunoreceptors,
the numerous kinases and adaptors that associate with their
intracellular tails, and the downstream signaling pathways that
lead to transcription of interleukins and other outputs. Other
contributions examine the roles of other receptors, co-stimulatory
signals, and innate immune responses in regulation of
immunoreceptor signaling. The spatial organization of the
immunological synapses connecting lymphocytes and
antigen-presenting cells is also discussed, along with the role of
the cytoskeleton in immunoreceptor function. Computational models
of the signaling processes complete the volume, making it essential
reading for systems biologists as well as all immunologists and
cell biologists interested in understanding how lymphocytes
function.
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