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Arachidonic Acid Metabolism and Tumor Initiation (Paperback, Softcover reprint of the original 1st ed. 1985)
Loot Price: R2,934
Discovery Miles 29 340
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Arachidonic Acid Metabolism and Tumor Initiation (Paperback, Softcover reprint of the original 1st ed. 1985)
Series: Prostaglandins, Leukotrienes, and Cancer, 2
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Prostaglandins, Leukotrienes, and Cancer is a multi-volume series
that will focus on an emerging area of cancer research. In 1968,
R.H. Williams first reported that elevated prostaglandin levels are
present in human medullary car- cinoma. Since that time, the
concept that arachidonic acid metabolites may be in- volved in
cancer has expanded to include every aspect of the disease from
cell transformation through metastasis. Prostaglandins and
leukotrienes are generic terms used to describe a family of
bioactive lipids produced from unsaturated fatty acids (principally
from arachidonic acid) via the cyclooxygenase and lipoxygenase
pathways, respec- tively. Cyclooxygenase products consist of
diverse products such as prosta- glandin E2 (POE ), prostacyclin
(POI ) and thromboxane A2 (TXA ), whereas 2 2 2 lipoxygenase
products consist of hydroperoxy fatty acids and mono-, di- and
tri-hydroxy acids including leukotrienes. The precursor fatty acids
for the cyclooxygenase and lipoxygenase pathways are present in
cellular phospholipids. This finding established an important
control point in their biosynthesis-the release of substrate. This
occurs in response to numerous stimuli that act at the cell
surface. Dr. Bengl Samuelsson's extensive study of the metabolism
of pros- taglandins indicated that they are rapidly inactivated on
a single pass through pulmonary circulation. Thus, they cannot act
as circulating hormones and appear to be made on demand in or in
the vicinity of target tissues leading to the concept that
prostaglandins are local hormones or autocoids.
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