The first chapter reviews actions on bone longitudinal growth,
muscle, kidney, calcium, nitrogen, phosphorus and potassium, body
composition, carbohydrate metabolism, insulin, lipids, protein
actions, coagulation and fibrinolysis, adipokines, cardiovascular
effects, and retina. Next, the authors discuss the values and
boundaries of various surgical approaches to achieve interbody
fusion, and introduce a novel fusion technique named extraforaminal
lumbar interbody fusion. Each indirect decompression procedure for
the intervertebral foramen is introduced in detail, and their
influence on intervertebral foramen parameters is discussed,
including foraminal height and foraminal area. This provides
detailed information on the quantitative decompression index, thus
proving helpful for surgeons. Following this, prodrugs are
examined, having been extensively studied in the field of drug
development. Continuous research in developing prodrugs/drug
conjugates has resulted in an improvement of the lipophilicy,
aqueous solubility, oral bioavailability, chemical stability,
prolongation of action, reduced toxicity and site specific drug
delivery of parent drugs. The susceptibility of germline stem cells
to genetic damage induced by oxaliplatin and its mechanism of
action is also discussed. Germ cells are responsible for the
transmission of genetic information from males to their progeny.
The authors evaluate parenteral nutrition-associated liver disease
and how it encompasses a variety of diseases ranging from steatosis
to fibrosis and cirrhosis. A systematic review of the literature is
executed to pool data from all individually documented patients to
evaluate the safety and efficacy of combined liver and inferior
vena cava resection in patients with colorrectal liver metastases
involving inferior vena cava. Research in subsequent chapter
examines how the development of purkinje cells in the postnatal
period in rats is accompanied by significant structural and
metabolic changes, this being the basis for their growth,
maturation, differentiation and functions. The authors evaluate the
in vitro leishmanicidal activity of the Vanillosmopsis arborea
essential oil and its major compoundd"-bisabolol against Leishmania
amazonensis in an effort to evaluate its role to treat diseases
caused by bacteria, fungi, and protozoa, such as leishmaniasis.
Since there are still only few data available for the understanding
of cellular and molecular functions of Neurensin genes in spite of
the expected critical roles in human brain function, the authors
present studies which will contribute to elucidating the mechanism
of brain disorders at the molecular level. The concluding chapter
focuses on the pharmacokinetic/pharmacodynamic properties of
emtricitabine, dosing recommendations, and monitoring in the oral
antiretroviral preexposure prophylaxis population.
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