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Pediatric Cancer, Volume 4 - Diagnosis, Therapy, and Prognosis (Hardcover, 2013 ed.)
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Pediatric Cancer, Volume 4 - Diagnosis, Therapy, and Prognosis (Hardcover, 2013 ed.)
Series: Pediatric Cancer, 4
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This entry in the series Pediatric Cancer offers comprehensive
information on a variety of cancers, concentrating on brain tumors,
the most common solid tumors and the leading cause of
cancer-related mortality in children. The contents are organized in
seven sections: Neuroblastoma, Medulloblastoma, Leukemia, Lymphoma,
Rhabdoid, Sarcoma and Miscellaneous Tumors. Coverage includes
pediatric medulloblastoma, and treatments including craniospinal
radiation followed by adjuvant chemotherapy. The contributors
explain diagnosis and chemotherapy of children with acute
lymphoblastic leukemia, and diagnosis of bone marrow involvement in
pediatric lymphoma patients. Ewing's sarcoma, a highly malignant
connective tissue neoplasm formed by the proliferation of
mesenchymal cells, receives extensive coverage, including targeting
of molecular pathways and chemotherapy and surgical treatment. The
roles of apoptotic genes, MYCN gene, MDM2, and SNP309, P13K
inhibitors, alternative splicing and microRNAs, activated leukocyte
cell adhesion molecule and inhibition by alu-like RNA in
neuroblastoma are discussed in detail. The book explores the
molecular genetics, diagnosis, prognosis and therapy of the
atypical teratoid/rhabdoid tumor (AT/RT). Among the most common
malignant neoplasms in children, AT/RT exhibits similarities with
other CNS tumors, which can lead to misclassification, as pointed
out in the book. The contributors discuss diagnosis of AT/RT type
using imaging technology, and describe new strategies, including
intensive multimodal therapy and high dose chemotherapy with
autologous stem cell transplantation that have shown improved
outcomes. Coverage of therapies includes total resection followed
by aggressive chemotherapy and radiation. Discussion includes
diagnosis and treatment of other pediatric tumors including
adrenocortical tumors, supratentorial primitive neuroectodermal
tumors, giant midline tumors, gastrointestinal stromal tumors,
ependymomas and intramedullary cavernoma. Pediatric Cancer:
Diagnosis, Therapy and Prognosis, Volume 4 includes contributions
by ninety-one contributors - oncologists, neurosurgeons,
physicians, research scientists and pathologists - representing
thirteen countries. The editor, M.A. Hayat, is a Distinguished
Professor in the Department of Biological Sciences at Kean
University, Union, New Jersey, USA.
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