One of the central questions in immunology is the understanding in
molecular terms of antigen-antibody interactions and of the cellu
lar recognition of antigens. It is hoped that this understanding
will extend eventually to the immunobiological basis of host
defense to infectious agents and of tissue damage or deranged cell
functions which stem from these reactions. A variety of natural and
artificial substances have been used as models for these studies.
Emphasis was placed upon substances of known and relatively
uncomplicated chemical structures. These included polysaccharides,
amino acid polymers, nu cleic acids and haptens. On the other hand.
until recently there has been very little information on protein
antigens. The complexity of these molecules posed an immense
chemical obstacle to precise immuno chemical analysis. Indeed, it
is this difficulty with proteins that spurred the synthesis and
immunological studies of amino acid poly mers. The control and
normal regulation of the immune system at the cellular-molecular
interface and the great majority of antigens asso ciated with
immune disorders are attributed to protein molecules. In the last
few years great advances have been made in the analysis and
synthesis of the antigenic sites of some proteins. The entire
antigenic structures of myoglobin and lysozyme and the partial anti
genic structures of several other proteins have been determined.
Moreover, in the past seven years several biological responses
resulting from the reactions of proteins and their peptides with
cells of the immune system were described."
General
Imprint: |
Springer-Verlag New York
|
Country of origin: |
United States |
Series: |
Advances in Experimental Medicine and Biology, 98 |
Release date: |
August 1978 |
First published: |
1978 |
Editors: |
M. Zouhair Atassi
|
Dimensions: |
244 x 170 x 26mm (L x W x T) |
Format: |
Paperback
|
Pages: |
513 |
Edition: |
Softcover reprint of the original 1st ed. 1978 |
ISBN-13: |
978-1-4615-8860-3 |
Categories: |
Books >
Medicine >
Clinical & internal medicine >
Diseases & disorders >
Immunology >
General
|
LSN: |
1-4615-8860-X |
Barcode: |
9781461588603 |
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