Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Protein Kinase C in Cancer Signaling and Therapy (Hardcover, Edition.)
Loot Price: R6,292
Discovery Miles 62 920
You Save: R1,999
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Protein Kinase C in Cancer Signaling and Therapy (Hardcover, Edition.)
Series: Current Cancer Research
Expected to ship within 12 - 17 working days
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Total price: R6,312
Discovery Miles: 63 120
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Protein kinase C (PKC), a family of serine-threonine kinases,
rocketed to the forefront of the cancer research field in the early
1980's with its identification as an effector of phorbol esters,
natural products with tumor promoting activity. Phorbol esters had
long been of interest to the cancer research field due to early
studies in the mouse skin carcinogenesis model, which showed that
prolonged topical application of phorbol esters promoted the
formation of skin tumors on mice previously treated with mutagenic
agents. Research in the last years has established key roles for
PKC isozymes in the control of cell proliferation, migration,
adhesion, and malignant transformation. In addition, there is a
large body of evidence linking PKC to invasion and cancer cell
metastasis. Moreover, it is now well established that the
expression of PKC isozymes is altered in various types of cancers.
More importantly, small molecule inhibitors have been developed
with significant anti-cancer activity. The relevance of PKC
isozymes in cancer signaling is therefore remarkable. This book
will have 4 sections. There will be 23 chapters. Each section will
have a brief introduction by an expert in the field (~ 1-2 pages).
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