This brief provides an in-depth overview of the physics of hadron
therapy, ranging from the history to the latest contributions to
the subject. It covers the mechanisms of protons and carbon ions at
the molecular level (DNA breaks and proteins 53BP1 and RPA), the
physics and mathematics of accelerators (Cyclotron and
Synchrotron), microdosimetry measurements (with new results so far
achieved), and Monte Carlo simulations in hadron therapy using
FLUKA (CERN) and MCHIT (FIAS) software. The text also includes
information about proton therapy centers and carbon ion centers
(PTCOG), as well as a comparison and discussion of both techniques
in treatment planning and radiation monitoring. This brief is
suitable for newcomers to medical physics as well as seasoned
specialists in radiation oncology.
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