.,"Indeed, an excellent and concise primer to the key issues and
themes addressed by the volume is included as Chapter 1. It is also
valuable as a source of comprehensive reviews of the major
experimental systems to use for reference and as an entry into the
literature for these systems.
For the new students in our laboratory, it is now required
reading."
Mike Harris, Center for RNA Molecular Biology, Case Western
Reserve University School of Medicine, Cleveland, OH 44106, USA
The discovery that RNA could act as a macromolecular catalyst in
the cell, signified a paradigm shift in molecular biology.
Ribozymes and RNA Catalysis takes the reader through the origins of
catalysis in RNA and necessarily includes significant discussion of
structure and folding. The main focus of the book concerns chemical
mechanism with extensive comment on how, despite the importance of
RNA catalysis in the cell, its origins are still poorly understood
and often controversial.
The reader is given an outline of the important role of RNA
catalysis in many aspects of cell function, including RNA
processing and translation. There has been a significant coming
together in the field of RNA in recent years and this book offers a
compelling review of the whole field to date.
Written by leading experts in their field, who in turn review
the structural and mechanistic data for all known ribozymes this
book is well suited for undergraduates, postgraduates and
researchers in catalytic chemistry as well as those in related
fields who require a unique overview of the subject.
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