Large artery stiffness is predictive of adverse cardiovascular
events and all cause mortality. This book presents a series of
in-vivo experimental studies investigating effects of structural
and functional changes on large artery stiffness. Novel analysis
methods for measurement of arterial stiffness indexes are discussed
and applied. Findings in acute inflammation, active and passive
changes in systemic pressure, aortic elastic laminae defects,
aortic calcification, and vasoconstrictor agents (angiotensin-II,
noradrenaline, and endothelin-1) in animal models are reported. The
vasodilating properties of the beta-antagonist and nitric oxide
donor, nebivolol, is investigated in the human iliac artery.
Changes in human forearm arterial stiffness during reactive
hyperaemia are studied with respect to the importance in clinical
quantification of endothelial dysfunction. Findings across these
studies provides new, quantitative contributions to the in-vivo
experimental investigation of the aetiology of large artery
stiffness related to structure and function of artery wall
properties This can lead to potential clinical applications and
techniques for assessment of cardiovascular risk.
General
Imprint: |
VDM Verlag Dr. Mueller E.K.
|
Country of origin: |
Germany |
Release date: |
April 2008 |
First published: |
April 2008 |
Authors: |
Mark Butlin
|
Dimensions: |
229 x 152 x 12mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
228 |
ISBN-13: |
978-3-8364-9788-6 |
Categories: |
Books >
Science & Mathematics >
Biology, life sciences >
General
|
LSN: |
3-8364-9788-3 |
Barcode: |
9783836497886 |
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