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Books > Science & Mathematics > Biology, life sciences > Molecular biology
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The Biochemistry of Retinoic Acid Receptors I: Structure, Activation, and Function at the Molecular Level (Paperback, Softcover reprint of the original 1st ed. 2014)
Loot Price: R3,510
Discovery Miles 35 100
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The Biochemistry of Retinoic Acid Receptors I: Structure, Activation, and Function at the Molecular Level (Paperback, Softcover reprint of the original 1st ed. 2014)
Series: Subcellular Biochemistry, 70
Expected to ship within 10 - 15 working days
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A role for vitamin A in living organisms has been known throughout
human history. In the last 100 years, the biochemical nature of
vitamin A and its active derivative, retinoic acid, its
physiological impact on growth processes and the essential details
of its mechanism of action have been revealed by investigations
carried out by researchers using vertebrate and more recently
invertebrate models to study a multiplicity of processes and
conditions, encompassing embryogenesis, postnatal development to
old age. A wealth of intercellular interactions, intracellular
signaling systems and molecular mechanisms have been described and
the overall conclusion is that retinoic acid is essential for life.
This book series, with chapters authored by experts in every aspect
of this complex field, unifies the knowledge base and mechanisms
currently known in detailed, engaging, well-illustrated, focused
chapters that synthesize information for each specific area. In
view of the recent explosion in this field, it is timely to publish
a contemporary, comprehensive, book series recapitulating the most
exciting developments in the field and covering fundamental
research in molecular mechanisms of vitamin A action, its role in
physiology, development and continued well-being and the potential
of vitamin A derivatives and synthetic mimetics to serve as
therapeutic treatments for cancers and other debilitating human
diseases. VOLUME I: Here, we present the first volume of a
multi-volume series on Retinoic Acid Signaling that will cover all
aspects of this broad and diverse field. One aim of Volume I is to
present a compilation of topics related to the biochemistry of
nuclear retinoic acid receptors, from their architecture when bound
to DNA and associated with their coregulators to their ability to
regulate target gene transcription. A second aim is to provide
insight into recent advances that have been made in identifying
novel targets and non-genomic effects of retinoic acid. Volume I is
divided into ten chapters contributed by prominent experts in their
respective fields. Each chapter starts with the history of the area
of research. Then, the key findings that contributed to development
of the field are described, followed by a detailed look at key
findings and progress that are being made in current, ongoing
research. Each chapter is concluded with a discussion of the
relevance of the research and a perspective on missing pieces and
lingering gaps that the author recommends will be important in
defining future directions in vitamin A research.
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