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Books > Professional & Technical > Mechanical engineering & materials > Materials science
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Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy (Hardcover, 2012 ed.)
Loot Price: R2,663
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Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy (Hardcover, 2012 ed.)
Series: Springer Theses
Expected to ship within 18 - 22 working days
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In his thesis, Matthias Junk takes an innovative approach to assess
the local structure and dynamics of biological and synthetic
amphiphilic macromolecules capable of transporting small molecules.
Replacing the latter with stable radicals, he uses state-of-the-art
electron paramagnetic resonance (EPR) spectroscopy to describe the
highly relevant transport function from the viewpoint of the guest
molecules. Such, he demonstrates that the functional structure of
human serum albumin in solution significantly differs from its
crystal structure - a consequence of the protein's adaptability to
host various endogenous compounds and drug molecules. Further, he
shows that the thermal collapse of thermoresponsive hydrogels and
dendronized polymers leads to static and dynamic heterogeneities on
the nanoscale. These heterogeneities bear consequences for the
material's hosting properties and enable unforeseen complex
catalytic functionalities.
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