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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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BLyS Ligands and Receptors (Hardcover, 2010 ed.)
Loot Price: R5,472
Discovery Miles 54 720
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BLyS Ligands and Receptors (Hardcover, 2010 ed.)
Series: Contemporary Immunology
Expected to ship within 10 - 15 working days
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Discovery of the BLyS (also known as BAFF) family of ligands and
receptors has yielded a paradigm shift in our view of B-lymphocyte
selection, survival, activation, and homeostasis. Previously, the
B-cell antigen receptor (BCR) was viewed as the sole mediator of
these parameters, in which BCR signals were not only dominant but
were also linearly related to consequent outcomes. However,
appreciating that BLyS signaling is an equal partner in
establishing and maintaining B-cell pools in- cated that additional
regulatory complexity - apparently based on population density and
homeostatic demands - had to be included in models of B-cell
behavior. This mounting interest was ampli?ed by evidence of a
clear relationship to autoim- nity. The resulting ?urry of research
activity has yielded a wealth of information and insights,
impacting basic concepts in B-cell tolerance and activation as well
as revealing novel translational strategies for autoimmunity,
neoplasia, and transplant tolerance. This book includes 12 chapters
that together yield an overview of these advances and ideas. The
initial excitement generated by associations with humoral
autoimmunity, coupled with profound B lineage phenotypes in
knockout mouse models, prompted immediate questions: What do these
receptors and cytokines look like, how do they interact, what cells
express them, and how does this inform our understating of their
biology? Indeed, probing the structural features of BLyS family
ligands and rec- tors has afforded substantial insight, as have
studies directed toward understanding the basic biological actions
of these molecules.
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