Progression of chronic diseases in general and chronic kidney
disease in particular has been traditionally viewed in the light of
various contributors to development of glomerulosclerosis and
tubulointerstitial scarring culminating in renal fibrosis. Indeed,
this dogma prevailed for decades underscoring experimental attempts
to halt fibrotic processes. Breakthrough investigations of the past
few years on stem/progenitor cell involvement in organ regeneration
caused a conceptual shift in tackling the mechanisms of
nephrosclerosis. It has become clear that the rate of progression
of chronic kidney disease is the net sum of the opposing trends:
degenerative fibrotic processes and regenerative repair mechanisms.
The latter part of this equation has been by and large ignored for
years and only recently attracted investigative attention. This
book revisits the problem of kidney disease by focusing on
regenerative mechanisms in renal repair and on the ways these
regenerative processes can become subverted by an intrinsic disease
process eventuating in its progression. Cutting-edge investigations
are summarized by the most experienced international team of
* Presents a comprehensive, translational source for all aspects
of renal stem cells, tissue regeneration, and stem cell therapies
for renal diseases in one reference work. This will ultimately
result in time savings foracademic, medical and pharma
* Experts in the renal stem cell system in kidney repair and
regeneration take readers from the bench research to new
therapeutic approaches, providing a common language for nephrology
researchers, fellows and other stem cell researchers. This enables
the discussion of development of stem cells and their use in the
repair and regeneration of the kidney."
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