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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Adenosine and Adenosine Receptors (Hardcover, 1990 ed.)
Loot Price: R6,285
Discovery Miles 62 850
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Adenosine and Adenosine Receptors (Hardcover, 1990 ed.)
Series: The Receptors
Expected to ship within 12 - 17 working days
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Historically, the major emphasis on the study of purinergic systems
has been predominantly in the areas of physiology and gross
pharmacology. The last decade has seen an exponential in- crease in
the number of publications related to the role of both adenosine
and A TP in mammalian tissue function, a level of interest that has
evolved from a more molecular focus on the identity of adenosine
and A TP receptor subtypes and the search for selective ligands and
development of radioligand binding assays by Fred Bruns and
colleagues (especially that for A receptors) that played z a highly
significant role in advancing research in the area. In the 60 years
since adenosine was first shown to be a potent hypotensive agent, a
considerable investment has been made by several pharmaceutical
companies-including Abbott, Byk Gulden, Takeda,
Warner-LambertlParke Davis, Boehringer Mann- heim, Boehringer
Ingelheim, Nelson/Whitby Research and CffiA- Geigy-as well as John
Daly's laboratory at the National Institutes of Health, to design
new adenosine receptor ligands, and both agon- ists and antagonists
with the aim of developing new therapeutic entiities. Numerous
research tools have derived from these efforts including:
2-chloroadenosine, R-PIA (~-phenylisopropyladeno- sine; NECA (5'
N-ethylcarboxamidoadenosine); CV1808; CI936; PD 125,944;
~-benzyladenosine; PACPX; CPX; CPT; XAC; CGS 15943 and CGS 21680.
Yet in the realm of therapeutics it was only in 1989 that adenosine
itself was approved for human use in the treatment of
supraventricular arrythmias.
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