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DNA Methylation and Complex Human Disease (Hardcover)
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DNA Methylation and Complex Human Disease (Hardcover)
Series: Translational Epigenetics
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DNA Methylation and Complex Human Disease reviews the possibilities
of methyl-group-based epigenetic biomarkers of major diseases,
tailored epigenetic therapies, and the future uses of
high-throughput methylome technologies. This volume includes many
pertinent advances in disease-bearing research, including obesity,
type II diabetes, schizophrenia, and autoimmunity. DNA methylation
is also discussed as a plasma and serum test for non-invasive
screening, diagnostic and prognostic tests, as compared to
biopsy-driven gene expression analysis, factors which have led to
the use of DNA methylation as a potential tool for determining
cancer risk, and diagnosis between benign and malignant disease.
Therapies are at the heart of this volume and the possibilities of
DNA demethylation. In cancer, unlike genetic mutations, DNA
methylation and histone modifications are reversible and thus have
shown great potential in the race for effective treatments. In
addition, the authors present the importance of high-throughput
methylome analysis, not only in cancer, but also in non-neoplastic
diseases such as rheumatoid arthritis.
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