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Modeling the Psychopathological Dimensions of Schizophrenia, Volume 23 - From Molecules to Behavior (Hardcover)
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Modeling the Psychopathological Dimensions of Schizophrenia, Volume 23 - From Molecules to Behavior (Hardcover)
Series: Handbook of Behavioral Neuroscience
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Modeling the Psychopathological Dimensions of Schizophrenia: From
Molecules to Behavior is the first book to offer a comprehensive
review of the new theoretical, clinical, and basic research
framework that considers psychotic illness as a group of
dimensional representations of psychopathology rather than as
traditional distinct categorical diagnoses. Psychotic illness,
typified by schizophrenia, is a devastating condition increasingly
recognized as a disorder of abnormal brain development and
dysconnectivity. Its complex etiology involves both genetic and
environmental factors, as well as the interplay among them. This
book describes the current understanding of the clinical and
pathological features of schizophrenia, with a particular focus on
the evolving conceptualization of schizophrenia and related
diagnostic categories of psychotic illness as combinations of
dimensional abnormalities. It provides an overview of modern
strategies for generating cellular and whole animal models of
schizophrenia as well as detailed reviews of the specific
experimental preparations and paradigms aimed at molecular,
developmental, and brain-network mechanisms that are the underlying
aspects of abnormal behavior and various aspects of schizophrenia.
This groundbreaking book is an authoritative overview of the
translational impact of emerging clinical insights on basic
research approaches in schizophrenia that will advance the reader's
understanding of the five major dimensions of psychopathology in
schizophrenia and related psychoses and resolve the genetic and
neurobiological underpinnings of these dimensions.
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