Engineered antibodies currently represent over 30% of
biopharmaceuticals in clinical trials and their total worldwide
sales continue to increase significantly. The importance of
antibody applications is reflected in their increasing clinical and
industrial applications as well as in the progression of
established and emerging production strategies. This volume
provides detailed coverage of the generation, optimization,
characterization, production and applications of antibody. It
provides the necessary theoretical background and description of
methods for the expression of antibody in microbial and animal cell
cultures and in transgenic animals and plants. There is a strong
focus on those issues related to the production of intrabodies,
bispecific antibody and antibody fragments and also to novel
applications in cancer immunotherapy.
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