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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Cell Engineering - Apoptosis (Hardcover, 2004 ed.)
Loot Price: R4,700
Discovery Miles 47 000
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Cell Engineering - Apoptosis (Hardcover, 2004 ed.)
Series: Cell Engineering, 4
Expected to ship within 10 - 15 working days
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The suppression of apoptosis by the IGF system is critical for
normal cell development, proliferation, differentiation and
motility. Aberrations in IGF signalling mechanisms contribute to
cell transformation, tumour progression and metastasis. Many
questions remain to be answered as to how exactly the IGF system
mediates its effects both in normal and tumour cells and how the
IGF-1R interacting proteins and downstream signalling cascades are
regulated. The importance of the IGF system is underscored by the
significant interest in the development of anti-IGF therapies for
IGF sensitive cancers. Future developments in cancer therapy are
likely to focus on methods to target these therapies to diseased
but not normal cells. 14. Acknowledgements We would like to thank
Kurt Tidmore for preparing the illustrations. The Health Research
Board of Ireland and Science Foundation Ireland are grateful
acknowledged for funding. 15. References Adamo M., Roberts C. T.,
Jr. and LeRoith D. (1992) How distinct are the insulin and insul-
like growth factor I signalling systems? Biofactors 3, 151-7. Adams
T. E., Epa V. C., Garrett T. P. and Ward C. W. (2000) Structure and
function of the type 1 insulin-like growth factor receptor. Cell
Mol Life Sci 57, 1050-93. Adler V., Polotskaya A., Wagner F. and
Kraft A. S. (1992) Affinity-purified c-Jun ami- terminal protein
kinase requires serine/threonine phosphorylation for activity. J
Biol Chem 267, 17001-5.
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