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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Oxidative Stress Mechanisms and their Modulation (Paperback, Softcover reprint of the original 1st ed. 2014)
Loot Price: R3,415
Discovery Miles 34 150
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Oxidative Stress Mechanisms and their Modulation (Paperback, Softcover reprint of the original 1st ed. 2014)
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Research over the years has demonstrated that free radicals
mediated oxidative stress lies at the helm of almost all
patho-physiological phenomena. These findings emphasize on the need
to understand the underlying molecular mechanism(s) and their
critical role in the pathogenesis. This book aims to focus on these
areas to provide readers a comprehensive outlook about the major
redox sensitive pathways and networks involved in various disease
conditions. In the first chapter of the book, basic information
about the oxidative stress, its generation, its biomarkers and its
role in body are discussed. In the next three chapters, the role of
oxidative stress in various pathologies ranging from neurological
disorders, to cardiovascular diseases, cancers, metabolic diseases
and ageing have been described. Chapter 5 cumulatively describes
the most important molecular signaling pathways that are affected
by reactive oxygen species (ROS). These are the mechanisms which
are common denominators in various pathological states. In the next
part of the book, various antioxidant strategies to target and
mitigate ROS have been discussed with details on the mechanisms.
Selenium, being the research focus and interest of the authors for
years, the role of selenium as an antioxidant as part of
selenoproteins has been included in the book. Finally, the book
culminates with authors’ perspective on the future of the redox
biology field. Throughout the book, efforts have been made to use
simplified language and suitable figures for ease to understand the
contents. Although the authors have tried to touch on all the
different aspects of oxidative stress in detail, the fact that it
is a continuously growing field with updates coming every day,
there might be some areas which might not be described in depth.
This book is designed for students, young scientists to get
acquainted with the redox biology. Overall, this book is a
reference to understand the redox regulation of cellular signaling
pathways involved in pathogenesis.
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