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Books > Medicine > Other branches of medicine > Pharmacology
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Lipoic Acid - Energy Production, Antioxidant Activity and Health Effects (Paperback)
Loot Price: R1,996
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Lipoic Acid - Energy Production, Antioxidant Activity and Health Effects (Paperback)
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The recognition of oxidative stress as a major factor in health,
aging, and disease has led to a surge in research aimed at
uncovering effective countermeasures in the form of antioxidants.
Unique in its two-fold protective function, alpha-lipoic acid has
drawn unprecedented interest as a coenzyme in mitochondrial energy
metabolism and as an antioxidant and cell redox modulator. Mounting
data regarding its potential health benefits demands an
authoritative, single-source reference to codify current knowledge
and guide future research. A state-of-the-science compilation,
Lipoic Acid follows the history of this potent coenzyme and the
latest discoveries regarding the chemistry, biological action, and
significance in energy production, antioxidant activity, and
health. The book is divided into three sections: * Section I:
Discovery and Molecular Structure reviews the early studies leading
to the discovery of alpha-lipoic acid and explains the molecular
structure, biosynthesis, and the characterization of lipoic acid
and its chemical derivatives. * Section II: Metabolic Aspects
describes in detail the human pharmacokinetics of alpha-lipoic acid
including the lipoic acid-derived dehydrogenase complexes and their
roles in energy metabolism. It also explains antioxidant activity
and redox modulation and how lipoic acid induces Phase II
detoxification enzymes through activation of Nrf2-dependent gene
expression. * Section III Clinical Aspects discusses enzyme
deficiency disorders and the effects of lipoic acid on insulin. It
defines lipoic acid influence on signaling pathways and
AMP-activated kinase, and considers the therapeutic implications
for treatment of metabolic syndromes and the improvement of
mitochondrial function by lipoic acid supplementation.
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