Many developments in immunology have occurred over the past 10
years that give us a better understanding of the immune system and
its dysfunctions. Refined mapping of the major histocompatibility
complex MHC; elucidation of its gene structure and polymorphism, as
well as the molecular basis of MHC restriction; the arrangement,
expression, and regulation of immunoglobulins; definition of the
structure of the T cell receptor and organization of its genes; and
the characterization of soluble factors involved in cell/cell
interactions and cloning of their genes are among the major
accomplishments. Volumes I and II build on these developments in
basic immunology to introduce animal models of various diseases,
corresponding human studies, and the genetic analysis of autoimmune
traits at the patient population level. The book will be a
tremendous asset to immunologists, geneticists, and physicians in
various areas of clinical subspecialties.
General
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