Directed metalation is recognized as one of the most useful
methodologies for the regio- and stereoselective generation of
organometallic species, the generation of which necessarily leads
to the selective formation of organic products. Cyclometalation
using Li, Mn, and Pd, and directed hydrometalation and
carbometalation using Al and Zn, have been utilized for regio-
and/or stereoselective synthesis for decades. Recently, a new
chelation-assisted methodology has been developed not only for
controlling regio- and stereoselectivity of reactions, but also for
accelerating reactions. In particular, chelation-methodology has
been utilized as a new activation method, in which a carbon-metal
bond is generated directly from a C-H bond; a reaction rarely
achieved using conventional methods. A wide variety of catalytic
functionalization reactions of C-H bonds by the utilization of a
chelation, have been developed recently and are comprehensively
discussed in this book by leading experts. In addition, new
approaches to directed hydrometalation and directed carbometalation
as a key step are also discussed. A unique stereo- and
regioselective hydroformylation has been developed through the
utilization of directed hydrometalation. The regioselective
Mizoroki-Heck reaction is another example in which directed
carbometalation can be used to achieve a high regioselectivity.
These examples emphasize how these innovative methodologies are
contributing to different fields of chemistry.
General
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