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The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research - Workshop Summary (Paperback)
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The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research - Workshop Summary (Paperback)
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Traditional preclinical mouse models of cancer have been very
useful for studying the biology of cancer, however they often lack
key characteristics of human cancers. As a result, many novel drug
candidates fail in human clinical trials despite evidence of drug
efficacy in those preclinical models. Thus, researchers are seeking
new approaches to augment preclinical knowledge before undertaking
clinical trials for human patients. Recently, there has been
renewed interest in comparative oncology - the study of naturally
developing cancers in animals as models for human disease - as one
way to improve cancer drug development and reduce attrition of
investigational agents. Tumors that spontaneously develop in pet
dogs and other companion animals as a result of normal aging share
many characteristics with human cancers, such as histological
appearance, tumor genetics, biological behavior, molecular targets,
and therapeutic response. In June 2015 the Institute of Medicine
hosted a workshop to examine the rationale and potential for
integrating clinical trials for pet patients with naturally
occurring cancers into translational cancer research and
development. Participants discussed the research needs, strategies,
and resources to support greater integration of clinical trials for
pets with cancer into translational research pathways, and
challenges and potential solutions for facilitating that
integration. This report summarizes the presentations and
discussions from the workshop. Table of Contents Front Matter
Workshop Summary Appendix A: Statement of Task Appendix B: Workshop
Agenda
General
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