Chromatin is DNA plus the proteins (and RNA) that package DNA
within the cell nucleus. The primary functions of chromatin are: to
package DNA into a smaller volume to fit in the cell, to strengthen
the DNA to allow mitosis and meiosis and prevent DNA damage, and to
control gene expression and DNA replication. In this book, the
authors present topical research in the study of chromatin
including the varied functions of aurora kinases A and B in mitosis
and carcinogenesis; the chromatin state of pluripotent stem cells;
MITF meets chromatin in melanoma; the state of chromatin as an
integrative indicator of cell stress; analysing DNA damage and its
repair throughout entire genomes; the cloning process, structural
characterisation of Revolver transposon and its patented
application for chromosome tags; DNA damage and Rad16; and
glucocorticoid-induced chromatin remodelling.
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