In recent years a growing number of proteases have been
identified that catalyse peptide bond hydrolysis in the plane of
the cellular membrane. These so-called intramembrane-cleaving
proteases (I-CLiPs) are involved in a diverse range of cellular
processes, including cell regulation, signalling, quorum sensing,
protein processing, lipid metabolism and the unfolded protein
response. Some I-CLiPs play critical roles in diseases such as
Alzheimer s and viral infection. The authors, who are all world
leaders in this exciting field of cell biology, provide an overview
of the various proteases including recent data derived from the
structural determination of some of the I-CliPs, and discuss the
various roles that these proteases play in biology and disease. The
aim of this book is to provide an update on this emerging group of
unusual but important proteases for both the specialist and those
with a broader interest in proteases. Amongst the target audience
will be protease researchers, enzymologists, those working in
academia and the pharmaceutical industry on biological processes
and diseases involving I-CLiPs."
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