Is adaptive randomization always better than traditional
fixed-schedule randomization? Which procedures should be used and
under which circumstances? What special considerations are required
for adaptive randomized trials? What kind of statistical inference
should be used to achieve valid and unbiased treatment comparisons
following adaptive randomization designs? Modern Adaptive
Randomized Clinical Trials: Statistical and Practical Aspects
answers these questions and more. From novel designs to
cutting-edge applications, this book presents several new and key
developments in adaptive randomization. It also offers a fresh and
critical look at a number of already-classical topics. Featuring
contributions from statisticians, clinical trialists, and
subject-matter experts in academia and the pharmaceutical industry,
the text: Clarifies the taxonomy of the concept of adaptive
randomization Discusses restricted, covariate-adaptive,
response-adaptive, and covariate-adjusted response-adaptive (CARA)
randomization designs, as well as randomized designs with treatment
selection Gives an exposition to many novel adaptive randomization
techniques such as brick tunnel randomization, targeted least
absolute shrinkage and selection operator (LASSO)-based CARA
randomization, multi-arm multi-stage (MAMS) designs, to name a few
Addresses the issues of statistical inference following
covariate-adaptive and response-adaptive randomization designs
Describes a successful implementation of a single pivotal phase
II/III adaptive trial in infants with proliferating hemangioma
Explores some practical aspects of phase II dose-ranging studies
and examines statistical monitoring and interim analysis issues in
response-adaptive randomized clinical trials Modern Adaptive
Randomized Clinical Trials: Statistical and Practical Aspects
covers a wide spectrum of topics related to adaptive randomization
designs in contemporary clinical trials. The book provides a
thorough exploration of the merits of adaptive randomization and
aids in identifying when it is appropriate to apply such designs in
practice.
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