One family of viruses is responsible for the infection of many
species of vertebrates. These are the retroviruses whose genomic
RNA is used to support genetic information and ensures many
essential functions that are required for the formation of an
infectious viral particle. These functions depend on structures
formed by the folding of the genomic RNA. Structures and Functions
of Retroviral RNAs describes the formation of these structures and
their specific interactions with nucleic acids and proteins. In
light of recent advances in molecular virology, it provides an
understanding of the various facets of the retroviral genome. It
emphasizes in particular that the study of the structure-function
relationship of retroviral RNAs is a driving force behind increased
research into HIV-1, the main causal agent of AIDS. Indeed, one of
the challenges of pharmacology lies in the exploitation of several
targets which allow us to anticipate and stem the emergence of
resistance to anti-HIV drugs. The book also presents structures and
interactions that may be potential future targets in this regard.
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