Streptomycetes are unusually complex bacteria that are abundant in
soil. They grow as branching filaments and form chains of spores.
Most importantly, they have an extraordinary ability to make
antibiotics, for which they are the main industrial source, as well
as other metabolites with medicinal properties. In recent years,
the search for new antibiotics and other drugs in streptomycetes
has been augmented by genomic studies, genome mining, and new
biotechnological approaches. With contributions from some of the
leading scientists in the field, this book documents recent
research and development in streptomycetes genomics, physiology,
and metabolism. With a focus on biotechnology and genomics, the
book provides an excellent source of up-to-date information. Topics
include: genome architecture * conjugative genetic elements *
differentiation * protein secretion * central carbon metabolic
pathways * regulation of nitrogen assimilation * phosphate control
of metabolism * gamma-butyrolactones and their role in antibiotic
regulation * clavulanic acid and clavams * genome-guided
exploration * gene clusters for bioactive natural products *
genomics of cytochromes p450. The book is essential reading for
research scientists, biotechnologists, graduate students, and other
professionals involved in streptomycetes research, antibiotic and
antimicrobial development, drug discovery, soil microbiology and
related fields. It is a recommended text for all microbiology
laboratories.
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