Volume 19, entitled Essential Metals in Medicine: Therapeutic Use
and Toxicity of Metal Ions in the Clinic of the series Metal Ions
in Life Sciences centers on the role of metal ions in clinical
medicine. Metal ions are tightly regulated in human health: while
essential to life, they can be toxic as well. Following an
introductory chapter briefly discussing several important
metal-related drugs and diseases and a chapter about drug
development, the focus is fi rst on iron: its essentiality for
pathogens and humans as well as its toxicity. Chelation therapy is
addressed in the context of thalassemia, its relationship to
neurodegenerative diseases and also the risks connected with iron
administration are pointed out. A subject of intense debate is the
essentiality of chromium and vanadium. For example, chromium(III)
compounds are taken as a nutritional supplement by athletes and
bodybuilders; in contrast, chromate, Cr(VI), is toxic and a
carcinogen for humans. The benefi cial and toxic effects of
manganese, cobalt, and copper on humans are discussed. The need for
antiparasitic agents is emphasized as well as the clinical aspects
of metal-containing antidotes for cyanide poisoning. In addition to
the essential and possibly essential ones, also other metal ions
play important roles in human health, causing harm (like the
metalloid arsenic, lead or cadmium) or being used in diagnosis or
treatment of human diseases, like gadolinium, gallium, lithium,
gold, silver or platinum. The impact of this vibrant research area
on metals in the clinic is provided in 14 stimulating chapters,
written by internationally recognized experts from the Americas,
Europe and China, and is manifested by approximately 2000
references, and about 90 illustrations and tables. Essential Metals
in Medicine: Therapeutic Use and Toxicity of Metal Ions in the
Clinic is an essential resource for scientists working in the wide
range from pharmacology, enzymology, material sciences, analytical,
organic, and inorganic biochemistry all the way through to medicine
... not forgetting that it also provides excellent information for
teaching.
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