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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Tumor Microenvironment (Hardcover, 1st ed. 2020)
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Tumor Microenvironment (Hardcover, 1st ed. 2020)
Series: Cancer Treatment and Research, 180
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This book addresses the biological processes relevant to the immune
phenotypes of cancer and their significance for immune
responsiveness, based on the premise that malignant cells
manipulate their surroundings through an evolutionary process that
is controlled by interactions with innate immune sensors as well as
the adaptive recognition of self/non-self. Checkpoint inhibitor
therapy is now an accepted new form of cancer treatment. Other
immuno-oncology approaches, such as adoptive cell therapy and
metabolic inhibitors, have also shown promising results for
specific indications. Immune resistance is common, however,
limiting the efficacy of immunotherapy in many common cancer types.
The reasons for such resistance are diverse and peculiar to the
immune landscapes of individual cancers, and to the treatment
modality used. Accordingly, approaches to circumvent resistance
need to take into account context-specific genetic, biological and
environmental factors that may affect the cancer immune cycle, and
which can best be understood by studying the target tissue and
correlated systemic immune markers. Understanding the major
requirements for the evolutionary process governing human cancer
growth in the immune-competent host will guide effective
therapeutic choices that are tailored to the biology of individual
cancers.
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